Views: 90 Author: Site Editor Publish Time: 2022-01-12 Origin: Site
Zeolites are considered as new biomaterials that can be used for medical treatment due to their low toxicity and good biocompatibility. This paper describes the interaction between zeolites and proteins. Zeolites specifically bind or react with proteins due to their ion exchange, surface properties and controlled pore structure, thus affecting the properties and behavior of proteins.
Proteins are the material basis of life. The behavior of proteins on the surface of materials plays an important role in the properties of material interfaces in living organisms. The adsorption of proteins on the material surface will affect processes such as blood coagulation, immune response, complement activation, particle phagocytosis, cellular and bacterial adhesion. Proteins are present on the surface of materials and can interact with them through intermolecular forces, such as chemical bonding, hydrophobic reactions and charge transfer reactions.
The main material properties that affect the interaction with proteins include size, morphology, charge, hydrophilicity and hydrophobicity, surface potential energy and surface groups. Among these, protein adsorption is the process by which molecules diffuse from solution, approach and adhere to the surface of a solid material. In addition to the surface properties of the protein and the material, adsorption depends on the solution environment in which the molecule interacts with the surface.
Zeolites have a lower cost than other porous materials loaded with proteins and have a stable structure. When combined with proteins to form composites, zeolites can be maintained in an effective and stable state. Moreover, zeolites have a defined and controlled structure. At present, the number of zeolites disclosed by the Structure Committee of the International Zeolite Association has reached 252. In addition, the metal ion exchange properties of zeolites allow zeolites of specific skeletons to contain different kinds of metal cations.
Controllable structures and variable compositions allow for a wide range of controllable compounds of zeolites and proteins. Amino acids exposed on the protein surface can be extended into ordered pores on the zeolite surface to form specific binding regions and modulate specific adsorption and conformational changes of proteins on the zeolite surface. The regulation of the conformation, behavior and properties of zeolite surface proteins, either positively or negatively, will play an important role in the biomedical field.
The use of metal ions with antimicrobial effect with the exchange of cations in the pores and cages of zeolites can give zeolites antimicrobial and antiviral properties. It has been reported in the literature that zeolites exchanged with Ag, Zn2, Cu2 and other cations have highly effective antibacterial effects. Among them, Ag is the most common antimicrobial material and its antimicrobial activity and cytotoxicity to humans and animals depend on the concentration of Ag. Although little research has been done on Zn2 and Cu2, recent reports suggest that they have antimicrobial potential and can inactivate various bacteria or viruses. Silver has good antibacterial properties.
Its antibacterial mechanism has three main components: (1) Ag binds to sulfhydryl groups in bacterial proteins, rendering the proteins inactive and causing the bacteria to fail to metabolize properly and die after survival. (2) Interference with nucleic acid molecules, so that they lose the ability to replicate; (3) Silver catalyzes the transformation of water molecules and internal oxygen to produce free hydroxyl radicals and reactive oxygen ions, which inhibit and kill the growth of bacteria and achieve bactericidal effects.
Based on the acid-base nature of zeolite surface, porosity and ion exchange properties, it has specific binding and interaction with proteins. The protein can be selectively adsorbed on the zeolite surface with specific orientation and adsorption conformation. Therefore, it has important applications in antibacterial and emergency hemostasis.
What are the applications of natural zeolite in the field of building materials?(2)
What are the applications of natural zeolite in the field of building materials?(1)
How to give your skin a DIY deep cleanse and detox with zeolite
What exactly is the difference between montmorillonite and zeolite?(2)
What exactly is the difference between montmorillonite and zeolite?(1)